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Another critical challenge involves the lack of standardized research methodologies, including inconsistency in dosing strategies, routes of administration, treatment durations, and outcome measures
Secondly, GLP-1RAs attenuate apoptosis induced by TNF- by ameliorating mitochondrial dysfunction related to activating the GLP-1R/cAMP/PKA and AMPK/SIRT1 pathway [94, 157, 158]
These side effects are usually less common at lower doses and may be noticeable at higher doses
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