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These reward phases are also linked since consummatory signals will depend on anticipated benefits (Kroemer & Small, 2016)
In the UK, the MHRA has approved semaglutide (Wegovy) and liraglutide (Saxenda) specifically for weight management in adults with obesity or overweight with weight-related comorbidities (as per NICE TA875 and TA664)
Together, they bind to specific regions of DNA called antioxidant response elements (AREs), which are located in the promoter or enhancer regions of NRF2 target genes
The evidence so far suggests that GLP-1s appear to modulate reward pathways in the brain that shape craving and compulsive drug use
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