The low placental transfer could be caused by the release of Dipeptidyl peptidase IV positive syncytiotrophoblast-derived extracellular vesicles released by the human placenta which degrade GLP-1 in uterine blood (63), as well as to the high molecular weight of GLP-1 agonists (4 73 kDa)
Jamali-Raeufy N, Alizadeh F, Mehrabi Z, Mehrabi S, Goudarzi M
Their presence would indicate a problem with injection technique, preparation, or in rare cases, individual sensitivity that should prompt a review of the protocol and professional consultation
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