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This work was supported by Basic Scientific Research Fund of Education Department of Liaoning Province, China (LJ212410161100 to Z-LL), Natural Science Foundation of Liaoning Province, China (2022-MS-326 to Z-LL), and Dalian Medical University's "Integrated Traditional Chinese and Western Medicine " Open Fund Project (ZXY2025JC04 to Z-LL)

Animal model studies demonstrate a biphasic response curve where low micromolar concentrations (110 M) produce maximal NF-B inhibition, while concentrations above 50 M show diminishing returns and, in some tissue types, paradoxical pro-inflammatory signaling

If there is no blood in the syringe when you pull back slightly, you can continue with the injection

approval estimated late 2027 to mid-2028

Lower volumes create higher concentrations, requiring smaller injection volumes