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"Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance." Diabetologia

A peptide that modulates VEGFR2 in a cell culture dish, or heals a rat tendon at 10 mcg/kg IP injection, has not been shown to survive oral delivery in a human at 500 mcg and reach musculoskeletal tissue at any meaningful concentration

doi: 10.1073/pnas.0600912103 84 MillerK

The gut and the brain are in continuous communication through the enteric nervous system, the vagus nerve, and the hypothalamic-pituitary-adrenal axis, or HPA axis

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