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And, based on the data so far, a significantly larger effect size than anything that came before

Semaglutide as a promising antiobesity drug [PMID: 30768766] Laboratory literature summary: Semaglutide as a promising antiobesity drug

GLP-1 agonists like semaglutide slow gastric emptying and extend satiety after eating the mechanism is peripheral (gut-based) rather than central (brain-based)