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Unlike its cyclic counterpart Melanotan II, MT-1 retains a linear backbone analogous to the 13-amino-acid natural -MSH sequence, differing primarily in a norleucine substitution at position 4 and a D-phenylalanine at position 7 (Nle-D-Phe--MSH), which confer receptor selectivity and enhanced metabolic stability

Gut Microbiome and DPP-4 Regulation of DPP-4: The gut microbiome may influence DPP-4 expression and activity