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As your dose increases over the months, the results pick up speed
This suggests that Retatrutides activity on GLP-1, GIP, and glucagon pathways interacts with underlying insulin sensitivity
If you have prediabetes or take additional diabetes medications, combining semaglutide with berberine might increase your risk of hypoglycemia (low blood sugar), particularly in the first weeks of treatment when your body is still adjusting
However, several practical differences can affect perceived onset
