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Which Form of B12 Is Most Effective

The problem is that translation from rodent models to human outcomes is notoriously unreliable, and we've been burned by promising animal data that didn't pan out in humans more times than anyone wants to count

however, the results did not reach statistical significance (Figure 4)

Cyanocobalamin works and is cheaper, but for ongoing optimization as part of a broader supplement strategy, methylcobalamin is the more direct choice