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Drug Metab Dispos 1994
Acetaminophen Toxicity and 5-Oxoproline (Pyroglutamic Acid): A Tale of Two Cycles, One an ATP-depleting Futile Cycle and the Other a Useful Cycle
Pediatr Nephrol 35(3):383397
Because of this rapid enzymatic degradation, native oral glutathione was found to have a baseline bioavailability of less than 1%, and a plasma half-life of roughly two minutes
Reduction of GSSG to GSH by Glutathione reductase allows to determine the total GSH content (free GSH + GSSG)
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