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Bacterial endotoxins are invisible, heat-stable, and can invalidate an entire study or skew your results
It would seem it is hardly covered in Med schools these days and there is an over emphasis on the recognition of it through the anaemia it causes whereas neurological symptoms usually occur before the anaemia
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Adding more water spreads that peptide through a larger volume, so each microgram sits in more millilitres and more units of solution
Malouf M et al
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