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Prior injuries, how the hands are being used, timing and severity of symptoms, and contributing factors such as other medical conditions should all be discussed

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Additionally, mast cells directly respond to gliadin fragments (part of the gluten protein) and release proinflammatory mediators.[ref] Related article: Celiac Genes Ehlers-Danlos, Hypermobility, and Mast Cell Activation: As mentioned above, mature mast cells are found in tissues and congregate in the connective tissue around lymphatic vessels, blood vessels, nerves, and skin

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