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The dermis and subcutaneous tissue are both part of an organ system, so, once a substance passes the epidermis, the potential risk of systemic complications increases
10.3164/jcbn.16-15 J Clin Biochem Nutr
Vranas KC, Lapidus JA, Ganzini L, Slatore CG, Sullivan DR
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While these problems are minor, they can still be uncomfortable
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