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Since the isolation of the cDNA in 1994, the work on the mammalian Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR) and Overview of Mutations/Polymorphisms MTHFR gene has resulted in significant advances in our understanding of its genomic organization, genetic variations and involvement in human disorders

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Despite the use of rodents and small mammals being commonplace in research, in particular for the development of novel therapeutic agents, caution still needs to be practiced when extrapolating research data to clinical applications