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Those who took GLP-1s for less than 18 months before discontinuing saw no significant risk reduction compared to the group on sulfonylureas at the end of the trial
Patients should be cautious
However, in randomized clinical trials in type 2 diabetes, semaglutide resulted in up to 3 times greater weight loss compared with other GLP-1RAs and up to twice as much in patients with obesity, approaching 15 kg (35)
Its significance in anaesthetic practice
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