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Average weight loss by medication: approximately 15% with Wegovy (STEP 1, 68 weeks) and up to 22.5% with Zepbound (SURMOUNT-1, 72 weeks), phentermine produces 58%, and Contrave produces approximately 56%
In context of a limited treatment paradigm focused on medical weight loss without a single FDA-approved pharmacotherapy for NASH, there exists significant interest in novel agents that may meaningfully alter the natural history of the disease
While optimizing diabetes control may indirectly support cognitive health through improved metabolic and vascular parameters, patients should discuss treatment decisions with their healthcare provider based on established evidence and individual health needs
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DISCUSSION None Acknowledgements ACKNOWLEDGMENTS CONFLICTS OF INTEREST: This study was supported by a grant from Bayer Korea, Co
