wikipedia glp 1 GLP-1 and Health: Beyond Weight Loss in the Ozempic Era What Is GLP-1? The Science

When to Expect Appetite Changes Initial Effects (1-2 Weeks): Semaglutide GLP-1 begins to show effects relatively quickly, but most users notice significant changes in appetite within the first 1 to 2 weeks

Addressing these proactively helps preserve energy, mood, and immune function

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Gradual improvements could be apparent after a few days

However, a significant direct effect of GLP-1 on pituitary LH release is less likely