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Another small trial, the Effect of Semaglutide 2.4 mg Once Weekly on Function and Symptoms in Subjects with Obesity-related Heart Failure with Preserved Ejection Fraction (STEP-HFpEF) trial assesed semaglutide efficay in patients with preserved LVEF (LVEF 45%) and obesity (BMI 30 kg/m 2 )
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This is why a single weekly injection of 0.5 mg to 2.4 mg maintains therapeutic levels for a full seven days
As delineated in Table 4, the current literature consists predominantly of low-level evidence (Level IV and V), including case reports, small observational cohorts, and post hoc subgroup analyses of larger trials
That distinction matters, and well cover why in the safety section below
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