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Animal studies show embryo-fetal toxicity
Maintenance Dose: Once B12 levels are normalized, a maintenance dose of 1,000 mcg monthly or every few months may be recommended
This preference for hydroxocobalamin in many countries is due to its long retention in the body
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A recent study has examined the effect of cobalamin supplementation on the outcomes of treatment for feline patients with severe cobalamin deficiency and histories suggesting chronic gastrointestinal disease.5 In this study, serum concentrations of methylmalonic acid normalized following parenteral cobalamin supplementation, indicating that cobalamin deficiency was the cause of the high methylmalonic acid in serum
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