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When tissue folate and cobalamin stores are intact, an abnormal increment of postmethionine-load homocysteinemia may also reveal a saturation of the transsulfuration pathway caused by dietary methionine excess that might be combined with transsulfuration defects (in cases with basal hyperhomocysteinemia) or with the homozygous thermolabile MTHFR defect (in cases with normal fasting homocysteine) (Cattaneo, 1999)
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Boguszewska-Czubara A, et al
Plasma amino acid profile in major depressive disorder: analyses in two independent case-control sample sets
If you have risk factors or these symptoms, your doctor may recommend testing for vitamin B12 deficiency
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