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Conflict of interest: KWS is employed by Lilly
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This is the main factor for how long a B12 injection takes to work, offering a significant advantage over oral supplements, which must be broken down by the digestive system before they can be distributed throughout the body
The direct influence of the E4 allele on FA-related bioenergetics (i.e., the transport and use of metabolites, in this case FAs, for energy) within the cerebrovasculature requires further attention, specifically in E4 carriers because of their increased cerebrovascular vulnerability observed with age which could impair nutrient transport to the brain and affect proper neuronal and glial functioning (Ojo et al., 2021)
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