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This is likely due to a reduction of peptide interactions (mainly A5 Cagri ) with ECL3 that is a consequence of the engagement of the lipidated N-terminus with the top segment of TM5/ECL2, facilitating flexibility of ECL3
PubMed Gwyer D, Wragg NM, Wilson SL
Presented for research literature review only Van Reeth O et al
The daily injection requirement means 365 injections per year
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