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Its levels are highest when we're young and decline pretty steeply with age, which is precisely why it's become such a focal point for Longevity Research

A key challenge in studying native GLP-1 is its extremely short in vivo half-life of approximately 12 minutes, owing to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), which cleaves the N-terminal His-Ala dipeptide from GLP-1 to produce the inactive metabolite GLP-1(936)amide

Long-Term: Research shows the best results come from consistent use over 12+ weeks as your muscles gradually increase carnitine stores

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Future studies should include newer GLP-1 receptor agonists and combinations, Orandi said