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Common Depo-Provera side effects in more than 5% of study participants include: Abdominal pain or discomfort (11.2%) Decreased sex drive (5.5%) Dizziness (5.6%) Headache (16.5%) Irregular bleeding (57.3% at 12 months, 32.1% at 24 months) Nervousness (10.8%) Not getting a period (55% at 12 months, 68% at 24 months) Weight gain, more than 10 pounds after two years (37.7%) Less Common Depo-Provera side effects in 1 to 5% of study participants include: Acne (1.2%) Alopecia (1.1%) Arthralgia (1%) Backache (2.2%) Bloating (2.3%) Breast pain (2.8%) Depression (1.5%) Dysmenorrhea (1.7%) Edema (2.2%) Fatigue (4.2%) Hot flashes (1%) Insomnia (1.0%) Leukorrhea (2.9%) Meg cramps (3.7%) Nausea (3.3%) Rash (1.1%) Vaginitis (1.2%) According to clinical trial data on the prescribing label, The median study duration was 13 months with a range of 1-84 months