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First, although we clearly demonstrated that IGF-1 attenuated cardiac fibrosis in an AngII-infusion mouse model, cardiac fibrosis is already present in pathological conditions, such as hypertension or myocardial infarction, when antifibrotic treatment is started in humans
Phase 2 trial (NEJM 2023) reported 24.2% mean weight loss at 48 weeks with 12 mg/week retatrutide, with gastrointestinal adverse events rising sharply at the 8 mg and 12 mg doses
FDA approved the first generic drug containing liraglutide in December 2024
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