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Mechanistically, SAHA pretreatment resulted in the decrease of histone H3 acetylated at lysine 9 (H3K9) of TLR4 gene and inhibited TLR4/MyD88 signaling pathway, finally protected from KA-induced brain damage [150]

The role of neuroprotectants in the therapeutic strategy to prevent or treat epilepsy is also discussed

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doi: 10.1016/S0140-6736(14)60107-0 4 MurtazaGVirkHUHKhalidMLavieCJVenturaHMukherjeeDet al