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When to contact your GP: Severe or persistent abdominal pain (potential pancreatitis) Right upper quadrant pain, fever, or jaundice (potential gallbladder disease) Unexplained muscle pain or weakness (if taking statins) Signs of dehydration from vomiting or diarrhoea No weight loss after 3-6 months of treatment Any concerns about medication side effects Regular follow-up allows healthcare professionals to optimise both weight management and cholesterol control, adjusting treatment strategies based on individual response and emerging evidence

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In contrast, 50 mg/kg Vutiglabridin with food restriction yielded continuous loss without plateau