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POLG-related disorders should be suspected in patients with a family history or suggestive symptoms of a POLG-related disorder, including but not limited to unexplained encephalopathy, refractory epilepsy (focal, myoclonic), status epilepticus at presentation, developmental delays, psychomotor regression, axonal sensorimotor neuropathy, myopathy cerebellar ataxia, ophthalmoplegia, or complicated migraine with occipital aura

These profiles are supported by biochemical and metabolic findings, but they are not recognized as formal clinical subtypes, nor are they used to stratify participants in clinical trials

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Refrigeration (2-8 degrees C) is preferred for long-term storage (months) Light: Keep away from direct sunlight and UV exposure

A standard semaglutide weight management protocol runs through five escalation phases before reaching maintenance dosing