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Efficacy and tolerability of albiglutide versus placebo or pioglitazone over 1 year in people with type 2 diabetes currently taking metformin and glimepiride: HARMONY 5
Adipose tissue macrophage infiltration and polarization toward the pro-inflammatory M1 phenotype further amplify systemic cytokine production in the context of central obesity, creating a self-reinforcing cycle of adipose dysfunction, systemic inflammation, and metabolic deterioration
For example, in one animal model, researchers found that a group of fatty acids known as short-chain fatty acids (SCFAs) significantly increase GLP-1 secretion
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