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Notably, studies have reported that DSIP-mediated analgesia occurs without the tolerance development typically seen with exogenous opioid compounds, suggesting a fundamentally different mechanism of interaction with the opioid system

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One study reported that the scaffold protein phosphatidylethanolamine binding protein 1 (PEBP1) binds to 15-lipoxygenase (15LOX) and directs it to PUFAs in the membrane, thereby facilitating ferroptosis [81]

& Vousden, K