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Thereafter, the homogenate was intermittently vortexed for 30 s every 10 min, and cooled on ice prior to centrifugation at 15,000 g at 4C for 30 min

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A study in adults aged 70 and older showed increased heteroplasmy linked to an increased depression score.[ref] Rare mitochondrial mutations that cause mitochondrial diseases are also linked to major depressive disorder.[ref] In fact, one study of people with hereditary (genetic) mitochondrial diseases showed that 54% had major depressive disorder and 17% had bipolar disorder.[ref] Outside of the mitochondrial genome, genes in the nuclear genome that code for proteins in the mitochondria are also linked to depression

Peptides are not FDA-approved drugs unless specifically indicated, and their use often falls under compounded or investigational therapies

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