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Non-selective c-Met inhibitors include crizotinib (PF-02341066), foretinib (XL-880), cabozantinib (XL-184), glesatinib (MGCD265), BMS-777607, and MK2461, which in addition to c-Met, can inhibit other tyrosine kinases, such as ALK, RON, VEGFR2, KIT, TIE2, PDGFR, VEGFR1, VEGFR3, RET, and FLT-3 [163,164,165], through binding to the ATP binding site on tyrosine kinases
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Any statements regarding the compound are derived from published scientific literature and have not been evaluated by the FDA
Aqu est cmo se ve en la prctica en diferentes rangos de peso: Tenga en cuenta que la cifra de 10 mcg/kg viene de investigacin en roedores y no ha sido validada en estudios de respuesta a la dosis en humanos