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[15] Therefore, high doses of biotin (in the tens or hundreds of milligrams) are generally reserved for research settings or specific medical conditions like certain metabolic disorders or experimental therapies (e.g., very high-dose biotin has been investigated in multiple sclerosis)

Vitamin B12 Overdose Is it possible to overdose on vitamin B12

Pharmacokinetic characterisation is comparatively thin, but distribution and elimination have been profiled in rats and dogs in a 2023 pharmacokinetic study (PMC9794587), which is useful context because most claims about systemic healing rest on animal exposure data rather than validated human pharmacology

Safety and Side Effects Most people tolerate B12 injections well, but like any injection, they may cause temporary discomfort, redness or soreness at the injection site

B12 shots deliver the vitamin directly into the bloodstream, ensuring maximum absorption