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TPPO significantly reduced the initial Ca 2+ peaks induced by 20 mmol/l glucose in the presence of the triagonist and attenuated the sustained intracellular Ca 2+ elevation in intact islets (Fig

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We also conducted an as treated analysis assessing only active treatment from first initiation until first break of treatment, where cohort members were followed from index date until first registration of suicide or suicide attempts, emigration, death, switching to the other study drug or reaching the end of their first treatment period