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amylovora may utilize the production of ROS as a tool to provoke host cell death for a more successful invasion of plant tissues (Venisse et al., 2001)
This reduces downstream transcription of inflammatory genes, Gut inflammation models: Studies in colonic inflammation models show KPV promotes mucosal healing, downregulates TNF- expression, and protects against ulcerative damage when delivered to inflamed intestinal tissue, and IL-1 receptor antagonism research: KPV mimics the KPT loop of IL-1 receptor antagonist degradation products, binding IL-1RI to terminate IL-1 signaling
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Centella is widely used because it is effective at low percentages
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