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doi: 10.1515/CCLM.2007.362, 19
As an antioxidant, glutathione helps neutralize free radicals and reactive oxygen species, which can cause cellular damage and contribute to various health issues, including liver disease
Treatment of Arabidopsis seedlings with 5 mM H 2 O 2 increased GCL activity and resulted in a shift from the less active reduced form to the more active oxidized form, as determined by activity assays and immunoblot analysis (Hicks et al., Conservation of the disulfide linkage that mediates the monomer/dimer transition of GCL occurs across the plant kingdom (Gromes et al., Nicotiana tabacum ), Agrobacterium tumefaciens (a-proteobacteria), and Xanthomonas campestris (-proteobacteria) showed that the two proteobacterial GCL remain monomeric during redox changes, even though the disulfide is retained
Free Radical Biol Med
10.3390/cells9051134 5 Al-SamerriaS.RadovickS
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