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In one of the most consequential healthcare deals of the year, President Trumps new drug-pricing pact with Eli Lilly and Novo Nordisk slashes the cost of blockbuster GLP-1 drugs like Wegovy and Zepbound, turning a luxury medicine into a mainstream benefitand forcing Ro, Hims, Mochi Health, and other telehealth players to rethink their most lucrative business model
Its high bioavailability, fast onset of action, and the physicians familiarity with subcutaneous administration favor its broad utilization
Any woman considering these treatments should complete breastfeeding first or choose alternative weight management strategies
According to NICE Clinical Knowledge Summaries and the British National Formulary (BNF), the recommended treatment regimens are: For patients without neurological involvement : Initial treatment: hydroxocobalamin 1 mg intramuscularly three times a week for 2 weeks Maintenance: hydroxocobalamin 1 mg intramuscularly every 3 months for life For patients with neurological involvement : Initial treatment: hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement Maintenance: hydroxocobalamin 1 mg intramuscularly every 2 months for life If neurological symptoms are present, treatment should be started urgently to prevent irreversible damage
It accesses doses lower than the usual starter doses as well as additional doses up to 25% of the standard maintenance dose
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