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Moreover, the actions of semaglutide to reduce body weight, improve glucose tolerance, and decrease circulating levels of triglyceride-enriched lipoproteins were not diminished in Glp1r Tie2/ mice, revealing that GLP-1Rs within the Tie2 expression domain, including IEL GLP-1R, are not required for these metabolic actions of semaglutide

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That is a five-month taper