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12) as a template and the mutagenesis primers listed in Supplementary Table 9

A.GoyalR.PearceW

a.k.a UMN in mice) of well characterized mouse models of TDP-43 pathology, both display prominent mitochondrial defects in a cell-type specific manner 16

The medium used to maintain the pellet was full chondrogenic medium (CM) consisted of DMEM (Gibco), 2 anti-anti (Gibco), 10 g/ml ITS (Thermo Fisher Scientific), 0.1 M Dexamethasone (Sigma-Aldrich, St