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The induction of angiogenesis in the CNS has been reported to promote pathological conditions such as brain tumor growth, and sterile-venous malformations (SVM) (Vallon and Chang 2014)

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Vegans and Vegetarians : Individuals following plant-based diets may be at a higher risk of B12 deficiency and can benefit from B12 supplementation through injections

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On the day of the assay, serial dilutions (7-fold dilutions, 7 concentrations per compound and one well containing only assay buffer) of test compounds were performed in duplicate in assay buffer to appropriate concentrations in 96-well plates (Greiner, U-shape #GR-650201) using a Biomek i7 liquid handler