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demonstrated that synbiotics significantly reduced the symptom burden of patients with acute radiation proctitis and improved patient quality of life, suggesting measurable clinical benefits for patients with localized rectal symptom profiles 220
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Dietary intake is modest estimated at 100-150 mg/day from fruits, vegetables, and meats and much of this is broken down by digestive enzymes (gamma-glutamyltranspeptidase and dipeptidases) in the intestinal lumen before absorption [1][2]
For instance, IMO-8400, a TLR7, 8, and 9 antagonists, exhibited clinical efficacy in a phase 2a randomized, placebo-controlled trial involving patients with moderate-to-severe plaque psoriasis
J.BenfeitoS.SilvaV.ChavarriaD.BorgesF.et al
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