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An increase in ROS accelerates tumor cell death, while GSH, as a key component in redox homeostasis, plays a crucial role in scavenging ROS and neutralizing exogenous metabolites in tumor cells [15]

Additionally, the same detox and metabolism triggered by the above can also cause a partial histamine breakdown and trapping of methylhistamine which can aggravate all the Sx you mention as well

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These preliminary steps prevent problems before they start

Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells