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[1] [7] Additionally, because glucagon promotes glycogenolysis and gluconeogenesis, there is a theoretical concern regarding glucose management in people with type 2 diabetes, although the GLP-1 and GIP components appear to counterbalance this effect in practice

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Brunst KJ, Enlow MB, Kannan S, Carroll KN, Coull BA, Wright RJ

From a clinical perspective, the right time for reflux repair in patients with medication-induced or medication-worsened reflux is when conservative measures, such as drug therapy and lifestyle changes, fail to provide clear and significant symptom relief

doi: 10.1104/pp.105.066803 46 MahmoodQ.AhmadR.KwakS.RashidA.AnjumN