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FIGURE 5 FIGURE 6 SCHEME 2 3.1.3 Pyrazolo[3,4-d]pyrimidone derivatives The fusion of theophylline , ITI-214 , and SCH-51866 backbones, followed by SAR exploration at N-7, C-2, and C-3 positions of the pyrazolo-pyrimidone core, resulted in the development of a series of pyrazolo-pyrimidone derivatives