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Understanding Fatigue: More Than Just Being Tired First, lets distinguish between ordinary tiredness and persistent fatigue

These findings indicate that hyperglycemia induces Mller cell ferroptosis via iron overload, lipid peroxidation and Xc - GSHGPX4 axis dysfunction, which further exacerbates neuroinflammation through microglial reactivation and impairs the BRB

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Connection 4 BH4 Depletion and eNOS Uncoupling Beyond Homocysteine Beyond its homocysteine-mediated BH4 oxidation effect, MTHFR impairment reduces BH4 recycling through a second mechanism: the dihydrobiopterin reductase (DHFR) enzyme that regenerates BH4 from BH2 requires dihydrofolate reductase activity an enzyme that uses NADPH to reduce both dihydrofolate to THF and BH2 to BH4