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Since sermorelin supports growth hormone production and TRT addresses testosterone, the therapies target different hormone systems and can complement each other under proper medical management
But "safe" comes with conditions
Nat Neurosci 21(6):851859
How IGF1 LR3 Works: Stimulates muscle cell proliferation and differentiation Activates satellite cells , leading to muscle repair and growth Increases glucose and amino acid uptake into muscle tissue Enhances protein synthesis and reduces muscle breakdown (catabolism) Promotes neuroregeneration and cellular recovery IGF1 mediates many of the growth-promoting effects of growth hormone and has potent anabolic effects on skeletal muscle. Florini et al., Annual Review of Physiology IGF1 is naturally stimulated by growth hormone via the liver
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