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Observational studies can identify patterns in real-world clinical data but they cannot fully exclude other confounding differences between patient groups which may explain the results

This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 17.99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access 119.00 per year only 9.92 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout References Ussher, J

These results suggested that GLP-1 expression was gradually decreased in CM, and also revealed that although the protein expression of GLP-1R was upregulated after NTG stimulation, the amount of GLP-1Rs that can be activated was decreased, so the activity of GLP-1R in the TNC in CM model was actually inhibited

Khan of Feinberg School of Medicine, Northwestern University

doi: 10.1016/j.ijbiomac.2023.124650 116 SoukasA