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We also tested a non-CRC model, the osteosarcoma U2OS cell line, which is wild-type for APC, KRAS and p53, and confirmed a similar 5FU-driven change in mitochondrial mass and morphology (Extended Data Fig
Epithelial cells, ECs, and vascular smooth muscle cells (VSMCs) in multiple organ systems may be the primary targets of TMAO-induced autophagy-dependent cell death
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