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Macrophages were induced from THP-1 cells and PBMCs using 10 nM phorbol-12-myristate-13-acetate (PMA), then induced into M1-like macrophages with lipopolysaccharide (1 g/mL) and IFN- (20 ng/mL) for 48 h, or induced into M2-like macrophages with IL-4 (20 ng/mL) for 48 h

Bottom line is, neither the benefits nor the risks of the vast majority of these peptides have been scientifically proven in humans