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These symptoms typically improve over time as the body adapts to the medication
Simply put, GLP-1 agonists mimic this hormone, and contribute towards controlling blood sugar levels and reducing weight
50 However, two phase 3 trials of selonsertib (an ASK-1 inhibitor) were terminated early due to a lack of efficacy in MASH adults with stage 3 (NCT03053050) and stage 4 (NCT03053063) fibrosis
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As noted in the GLP-1 agonist comparison table, in addition to FDA approval for T2DM alone, three of the currently available GLP-1s have been approved for the treatment of cardiovascular disease in the setting of type 2 diabetes
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